Controlled Synthesis of 3D Multi‐Compartmental Particles with Centrifuge‐Based Microdroplet Formation from a Multi‐Barrelled Capillary

TLDR

The study reports a controlled synthesis of micro multi‑compartmental particles using a centrifuge droplet shooting device (CDSD). Sodium alginate solutions introduced into a multi‑barreled capillary form droplets at the orifice under ultrahigh gravity and gelify in a CaCl₂ solution. The particles’ size, shape, and compartmentalization are controllable, and Janus particles co‑encapsulating Jurkat cells and magnetic colloids respond sensitively to magnetic fields while maintaining 91 % cell viability.

Abstract

Controlled synthesis of micro multi-compartmental particles using a centrifuge droplet shooting device (CDSD) is reported. Sodium alginate solutions introduced in a multi-barreled capillary form droplets at the capillary orifice under ultrahigh gravity and gelify in a CaCl2 solution. The size, shape, and compartmentalization of the particles are controlled. Co-encapsulation of Jurkat cells and magnetic colloids into Janus particles is demonstrated. The Janus particles present sensitive reaction toward magnetic fields, while the viability of the encapsulated cells is 91%.