Characterization of interleukin-7 and interleukin-7 receptor in the pathogenesis of rheumatoid arthritis

Abstract

We have identified, for the first time, regulators of IL-7 and IL-7R expression in RA fibroblasts, RA peripheral blood in vitro-differentiated macrophages, and endothelial cells. Our results document a novel role of IL-7 in RA angiogenesis.