Predicting the glomerular filtration rate from serum creatinine, serum cystatin C and the Cockcroft and Gault formula with regard to drug dosage adjustment

Abstract

The findings support the assumption that estimation of the decrease in GFR using Scr, Scyst and CG is, as regards their utilization in everyday practice, suitable for individuals with severely decreased GFR (<20 ml/min/1.73 m2) and for individuals with a decrease in GFR to levels >50 ml/min/173 m2. Estimation of the decrease in GFR using the above subgroups did not demonstrate significant differences among Scr, Scyst and CG. Using the above markers, estimation of the decrease in GFR is the least reliable with GFR values in the range of 20-50 ml/min/1.73 m2.