Neuronal NAD(P)H Oxidases Contribute to ROS Production and Mediate RGC Death after Ischemia

Abstract

The findings suggest that NAD(P)H oxidase activity in RGCs renders them vulnerable to ischemic death. Importantly, high levels of Nox1 NAD(P)H oxidase subunits in RGCs suggest that this enzyme could be a major source of ROS in RGCs produced by NAD(P)H oxidases.