Extra copies of c‐<i>myc</i> are more pronounced in nodular melanomas than in superficial spreading melanomas as revealed by fluorescence in situ hybridisation

Abstract

Our data show that c-myc copy number alterations differ in the two melanoma subtypes and are associated with the advanced stage of the disease. The less frequent amplification of the c-myc gene in metastatic lesions indicates that it may play an important role in the development of an invasive potential rather than in the metastatic process.