Extra copies of c‐<i>myc</i> are more pronounced in nodular melanomas than in superficial spreading melanomas as revealed by fluorescence in situ hybridisation

Andrea Treszl, Róza Ádány, Zsuzsa Rákosy, László Kardos, Ágnes Bégány, Katalin Gilde, Margit Balázs

Cytometry Part B Clinical Cytometry · 2004 · 32 citations · 32 references

DOIFull text

Open access

Abstract

Our data show that c-myc copy number alterations differ in the two melanoma subtypes and are associated with the advanced stage of the disease. The less frequent amplification of the c-myc gene in metastatic lesions indicates that it may play an important role in the development of an invasive potential rather than in the metastatic process.

References

32