Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine<i><scp>R</scp>yR2‐P2328S</i>hearts

Abstract

Flecainide (1 μm) rescues the RyR2-P2328S atrial arrhythmogenic phenotype by restoring compromised INa and λ, changes recently attributed to increased sarcoplasmic reticular Ca(2+) release. This contrasts with the increased arrhythmic incidence and reduced INa and λ with flecainide in WT.