Allelic Variants in the <i>CYP2C9</i> and <i>VKORC1</i> Loci and Interindividual Variability in the Anticoagulant Dose Effect Of Warfarin in Italians

Abstract

Our results clearly indicate VKORC1 as the gene with the largest contribution to MWWD. Analyzing only one tag SNP of VKORC1 gene (1173C>T), it is possible to foresee 20% of the total variability. Our results may contribute to give useful indications for clinicians especially in the initiation of therapy so as to avoid the risk of adverse events.