Menthol Induces Cell Death via the TRPM8 Channel in the Human Bladder Cancer Cell Line T24

Abstract

In the present study, we demonstrated that menthol can induce mitochondrial membrane depolarization via the TRPM8 channel in cells of the human bladder cancer cell line T24, resulting in cell death. It would be helpful to explore the precise mechanism of action of menthol in bladder cancer with a view to its possible use as intravesical chemotherapy.