Helvetica Chimica Acta · 1952 · 32 citations · 2 references
Natural SciencesChemistryPharmacologyDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryNatural Product DerivatizationOrganic SynthesisMedicinal Chemistry ApplicationsPiperidine ChemistryPiperidine SynthesisPyrrolidine Synthesis
Abstract 3:3‐Disubstituted 2,6‐dioxo‐piperidine derivatives can be prepared by means of a Michael condensation of disubstituted acetic acid nitriles or acetic acid esters with acrylonitrile or acrylic acid esters, followed by saponification and ring closure. Of the aminoalkylated phenyl‐dioxo‐piperidines described the 3‐diethylamino‐ethyl‐3‐phenyl‐2,6‐dioxo‐piperidine has an especially strong and specific parasympathicolytic action. For purposes of comparison some pyrrolidine and hexamethyleneimine compounds were also prepared.
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