Reactive Oxygen Species Play a Critical Role in Collagen-Induced Platelet Activation <i>via</i> SHP-2 Oxidation - Concepedia

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Reactive Oxygen Species Play a Critical Role in Collagen-Induced Platelet Activation <i>via</i> SHP-2 Oxidation

90

Citations

51

References

2013

Year

Ji Yong Jang, Ji Hyun Min, Yun Hee Chae, Jin Young Baek, Su Bin Wang, Su Jin Park, Goo Taeg Oh, Sang‐Hak Lee, Ye‐Shih Ho, Tong‐Shin Chang

Antioxidants and Redox Signaling

Abstract

We conclude that collagen-induced ROS production leads to SHP-2 oxidation, which promotes platelet activation by upregulating tyrosine phosphorylation-based signal transduction.

References

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