A Study of the Renin-Angiotensin System in the Nephrotic Syndrome

Abstract

Simultaneous measurements of the plasma concentrations of renin, renin-substrate, angiotensin II and aldosterone were made in seven patients with the nephritic syndrome and in five normal subjects studied under the same controlled conditions. Plasma renin-substrate concentration was found to be reduced in some patients. Although plasma renin concentration was frequently elevated, plasma angiotensin II and aldosterone concentrations were generally within the normal range.