Reactive Oxygen Species Contribute to Oxygen-Related Lung Injury After Acid Aspiration

Abstract

Oxygen administration results in a lung pathology known as oxygen toxicity. This effect is usually not significant if the duration of exposure is limited to < 24 h. In the presence of acute inflammatory lung injury, exposure to hyperoxia results in lung damage in a shorter time. We demonstrate that sufficiently decreased lung antioxidant reserve capacity may be accountable for this early toxicity.