<i>N</i>‐acetylcysteine reduces lipopolysaccharide‐sensitized hypoxic‐ischemic brain injury

Abstract

NAC provides substantial neuroprotection against brain injury in a model that combines infection/inflammation and HI. Protection by NAC was associated with improvement of the redox state and inhibition of apoptosis, suggesting that these events play critical roles in the development of lipopolysaccharide-sensitized HI brain injury.