Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation

Abstract

The data in this report show that FTY720 is a potential strong antitumor agent for cell line DU145, and provide the first evidence for involvement of caspase-3 in apoptosis of an androgen-independent prostate cancer cell line. Activation of such caspases may provide a means for eliminating androgen-independent prostate cancer in humans.