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<i>In Vitro</i>Inhibition of Cyclooxygenase and 5-Lipoxygenase by Alkamides from<i>Echinacea</i>and<i>Achillea</i>Species
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References
1994
Year
BiologyBiosynthesisBioorganic ChemistryAldehyde DehydrogenaseBiochemistryNatural SciencesMedicinePolyunsaturated AlkamidesSecondary MetabolitePorcine LeukocytesPharmacologyInhibitory ActivityOxidative Stress
Polyunsaturated alkamides isolated from Achillea species, Echinacea angustifolia DC., Anacyclus pyrethrum (L.) Link, and Aaronsohnia pubescens (Desf.) Bremer & Humphries, (Compositae) were shown to possess inhibitory activity in in vitro cyclooxygenase (sheep seminal microsomes) and 5-lipoxygenase (porcine leukocytes) assays. Activity appeared to depend on the particular structure of the alkamides.