Synthesis of 3,4-Dihydro-2H-pyrido[1,2-b]isoindol-1-one and 3,4-Dihydro-2H-pyrido[1,2-b]pyrrolidin-1-one Functionalized at the C-6 Position by an Intramolecular Horner-Wadsworth-Emmons Reaction

Abstract

Novel polyheterocycles were prepared from a new annellation reaction which proceeds by nucleophilic substitution followed by an intramolecular Horner-Wadsworth-Emmons reaction between imides and β-functionalized phosphonates.