Infliximab retreatment in adults and children with Crohn's disease: risk factors for the development of delayed severe systemic reaction

Abstract

Episodic infliximab retreatment--specifically, a distant second infusion--is associated with high rates of severe systemic reaction in adults, but not children. We recommend multiple early infusions of infliximab if retreatment is anticipated in adult patients to avoid the development of delayed severe systemic reactions.