Biological Studies of Lipophilic Mdp-Derivatives Incorporated in Liposomes

Abstract

Adjuvant activities of fatty acid derivatives of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) in saline, emulsified in Incomplete Freund Adjuvant (IFA) or incorporated in liposomes were compared. All derivatives were active when given in saline. The potency of MDP-L-Ala-glycerol mycolate was highly enhanced by administration in IFA of after incorporation in liposomes. These procedures had no effect on the activity of MDP-alpha-methyl-gamma-eta-butyl ester and MDP-alpha-methyl-gamma-eta-decyl ester although the presence of MDP could be demonstrated at the surface of the liposomes by anti-MDP antibodies.