Rate of Haptoglobin in Synthesis in Normal Man Determinations by the return to normal levels following hemoglobin infusion

Abstract

Following depletion of plasma haptoglobin by formation of a complex with hemoglobin, the return to normal levels was observed and analyzed kinetically. The daily synthetic rate approximated 30–50 per cent of the intravascular pool. More than half of this daily synthesis is consumed in association with the normal metabolism of plasma hemoglobin while some other catabolic mechanism(s) is responsible for the remainder.