Transfusion-Associated <i>Trypanosoma cruzi</i> Infection in a Non-Endemic Area

Abstract

Brief Reports15 November 1989Transfusion-Associated Trypanosoma cruzi Infection in a Non-Endemic AreaPeter Nickerson, MD, Pamela Orr, MD, Maria-Louise Schroeder, MD, Leila Sekla, MD, James B. Johnston, MDPeter Nickerson, MD, Pamela Orr, MD, Maria-Louise Schroeder, MD, Leila Sekla, MD, James B. Johnston, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-10-851 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOpportunistic infections have become a major cause of morbidity in the immunocompromised host. In patients with neutropenia, such infections often arise from their own indigenous flora; however, another potential mode of infection is the transmission of blood-borne organisms by transfusions. Patients with granulocytopenia who receive multiple blood products during chemotherapy are especially prone to transfusion-associated infections. We describe the first case of transfusion-associated acute Chagas disease in a nonendemic area of North America.Case ReportIn June 1986, a 1-year-old infant presented with a cerebral thrombosis and was subsequently found to have protein S deficiency. When the family was screened,...References1. Hudson L and Hay F. Practical Immunology. Oxford: Black well Scientific Publications; 1980. Google Scholar2. Kohl S, Pickering L, Frankel L, and Yaeger R. Reactivation of Chagas' disease during therapy of acute lymphocytic leukemia. Cancer. 1982;50:827-8. CrossrefMedlineGoogle Scholar3. Amato Neto V, Molinari H, Siqueira A, and Lucas R. Análise, por meio de reaçãe de fixação do complemento, do risco de aquisicao da doença de Chagas através de hemoterapia, por parte de pacientes politransfundidos. Revista Goiana de Medicina. 1975;21:1-9. Google Scholar4. Mattosinho-Franca L, Lemos S, and Fleury R. Moléstia de Chagas cronica associada a leucemia linfática. 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