MASSIVE DOSE ARSENOTHERAPY OF EARLY SYPHILIS BY INTRAVENOUS DRIP METHOD

Abstract

Previous papers have dealt with the pharmacologic work underlying the adoption of the continuous intravenous drip method,¹the clinical results in earlier series,²the organization of the supervisory committee,³the technical considerations for the administration of the drug,⁴the serologic⁵and chemical studies,⁶the organization of the follow-up clinic, under the direction of Dr. Evan Thomas⁷and Dr. Bruce Webster,⁸and the public health aspects.⁹ <h3>THE PLAN OF STUDY</h3> Four groups of patients are included in the present summary (table 1). Group 1, studied in 1933, consisted of 25 patients²who were given an average of 4 Gm. of neoarsphenamine over the course of five days. Group 2, studied in 1938, comprised 86 men¹⁰treated in the same manner. Groups 1 and 2 constitute the neoarsphenamine series of 111 patients. Group 3, studied in 1938 and 1939, included 157