Effect of Cortisone on Growing Bones of the Rat

Abstract

When cortisone acetate in appropriate doses is administered to growing rats, a dense zone composed of spicules of calcified cartilagenous matrix encased in bone appears at the growing ends of the bone. The width of this zone may be correlated with the duration of administration of the hormone. It is concluded that this area of increased density results from a disturbance in normal osteolytic activity.