A Controlled Trial of Naltrexone Augmentation of Nicotine Replacement Therapy for Smoking Cessation

Abstract

The 100-mg dose of naltrexone hydrochloride appears the most promising for augmenting the efficacy of the nicotine patch on smoking cessation outcomes but requires further study. The significant weight reduction with low-dose naltrexone therapy suggests that it may be useful as a second-line treatment for weight-concerned smokers.