Publication | Closed Access
Total Synthesis of Indole and Dihydroindole Alkaloids. XIII. Further Chemistry of Catharanthine
22
Citations
17
References
1978
Year
Bioorganic ChemistryBiochemistryDihydroindole AlkaloidsSpecific HydroxylationsNatural SciencesFurther ChemistryTotal SynthesisOrganic ChemistryAcid LactonePharmacologyDerivative (Chemistry)Synthetic ChemistrySteroid MetabolismSteric RequirementsNatural Product Synthesis
Abstract Further investigations on the chemistry of catharanthine have provided information, valuable in the estimation of reactivity and steric requirements of the skeleton. Specific hydroxylations at C(3), C(4) and C(18) have allowed the preparation of several derivatives including (3R, 4 R)‐3‐hydroxy‐3, 4‐dihydrocatharanthine ( 7 ); (3R,4 R)‐3, 4‐dihydroxycatharanthinic acid lactone ( 15 ); 18‐decarbomethoxy‐18‐hydroxycatharanthine ( 40 ).
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