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Inhibition of Cyclic-AMP Phosphodiesterase in Human Lymphocytes by Physiological Concentrations of Hydrocortisone
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1975
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Animal PhysiologyMolecular PharmacologyHuman LymphocytesAdrenal GlandSodium HomeostasisMedicinePhysiologyNeuropharmacologyPhosphodiesterase ActivityExperimental PharmacologyCyclic-amp PhosphodiesteraseBeef Heart ExtractPhysiological ConcentrationsEndocrinologyPharmacologyGlucocorticoidCamp Phosphodiesterase Activity
The effect of hydrocortisone on cAMP phosphodiesterase activity in human lymphocytes and beef heart extract was investigated. At all substrate concentrations tested, inhibition of phosphodiesterase activity was demonstrated when both physiological and pharmacological concentrations of hydrocortisone were used (1.4 × 10-3M to 1.4 × 10-7M).