Perioperative Glycine Treatment Attenuates Ischemia/Reperfusion Injury and Ameliorates Smooth Muscle Dysfunction in Intestinal Transplantation

Abstract

The data indicate that perioperative glycine treatment reduces the molecular and cellular inflammatory response within the grafts and improves smooth muscle dysfunction after transplantation. Therefore, the glycine-activated chloride channel on resident and infiltrating leukocytes could be a promising pharmacologic target to attenuate ischemia/reperfusion injury after ITx.