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Regiospecific Synthesis of 1,4,5-Trisubstituted-1,2,3-triazole via One-Pot Reaction Promoted by Copper(I) Salt
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2005
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Novel OrganocatalystsOne-pot Reaction PromotedEngineeringDiversity Oriented SynthesisFirst ExampleOrganic ChemistryOrganometallic CatalysisCatalysisChemistrySynthetic Chemistry1,4,5-Trisubstituted-1,2,3-triazole DerivativesRegiospecific Synthesis
A method for the regiospecific synthesis of 1,4,5-trisubstituted-1,2,3-triazole catalyzed by copper(I) iodide was developed. This is the first example of a regiospecific synthesis of 5-iodo-1,4-disubstituted-1,2,3-triazole, which can be further elaborated to a range of 1,4,5-trisubstituted-1,2,3-triazole derivatives.