Development and validation of an HPLC method for the rapid and simultaneous determination of 6-mercaptopurine and four of its metabolites in plasma and red blood cells

Validation of high-performance liquid chromatography methods for pharmaceutical analysis

Ghulam Shabir · Journal of Chromatography A · 2003 · 767 citations

Pharmacy, Pharmaceutical Analysis, Pharmaceutics +14

Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

William E. Evans, Michelle Horner, Ya Qin Chu et al. · The Journal of Pediatrics · 1991 · 399 citations

Medicine, Pharmacology, Toxicology +17

Simultaneous determination of 6-thioguanine and methyl 6-mercaptopurine nucleotides of azathioprine in red blood cells by HPLC

Thierry Dervieux, Roselyne Boulieu · Clinical Chemistry · 1998 · 210 citations · Full text

Pharmacy, Biochemistry, Pharmacology +13

Analysis of thiopurine methyltransferase variant alleles in childhood acute lymphoblastic leukaemia

Howard L. McLeod, Sally A. Coulthard, Angela Thomas et al. · British Journal of Haematology · 1999 · 128 citations · Full text

Medicine, Hematology, Pharmacology +15

Liquid Chromatography–Tandem Mass Spectrometry Analysis of Erythrocyte Thiopurine Nucleotides and Effect of Thiopurine Methyltransferase Gene Variants on These Metabolites in Patients Receiving Azathioprine/6-Mercaptopurine Therapy

Thierry Dervieux, G. P. Meyer, Robert Barham et al. · Clinical Chemistry · 2005 · 112 citations · Full text

Pharmacy, Pharmacology, Chromatographic Analysis +16