Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase

K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors

David B. Whyte, Paul T. Kirschmeier, Tish Hockenberry et al. · Journal of Biological Chemistry · 1997 · 872 citations · Full text

Direct Demonstration of Geranylgeranylation and Farnesylation of Ki-Ras in Vivo

Cheryl A. Rowell, James J. Kowalczyk, Michael D. Lewis et al. · Journal of Biological Chemistry · 1997 · 365 citations · Full text

Phase I and Pharmacokinetic Study of Farnesyl Protein Transferase Inhibitor R115777 in Advanced Cancer

J. Zujewski, Ivan D. Horak, C.J. Bol et al. · Journal of Clinical Oncology · 2000 · 265 citations

Crystallographic Analysis of CaaX Prenyltransferases Complexed with Substrates Defines Rules of Protein Substrate Selectivity

Tim Reid, K.L. Terry, Patrick J. Casey et al. · Journal of Molecular Biology · 2004 · 258 citations

Biochemistry, Protein Assembly, Natural Sciences +6

A Phase I trial of the farnesyl transferase inhibitor SCH66336: evidence for biological and clinical activity.

Alex A. Adjei, Charles Erlichman, J. Nathan Davis et al. · PubMed · 2000 · 243 citations

Chemoprevention Strategy, Pathology, Pharmacotherapy +17