Journal of the American Chemical Society · 2011 · 178 citations · 51 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistryHalogen ChemistryHeterocycle SynthesisAsymmetric CatalysisAsymmetric Heterocycle SynthesisAsymmetric SynthesisChiral Product SynthesisEnantioselective Synthesis
A novel asymmetric halogenation/semipinacol rearrangement reaction catalyzed by cinchona alkaloid derivatives was developed. Two types of β-haloketones (X = Br, Cl) were obtained with up to 95% yield and 99% enantiomeric excess. The desired (+) and (-) enantiomers of the β-haloketones were readily obtained.
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Asymmetric Organic Catalysis with Modified Cinchona Alkaloids
Shi‐Kai Tian, Yonggang Chen, Jianfeng Hang et al. · Accounts of Chemical Research · 2004 · 618 citations
Enantioselective Bromolactonization of Conjugated (<i>Z</i>)-Enynes
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