CARCINOMA OF THE CERVIX OF MICE RECEIVING ESTROGENS

Abstract

During the past three years hyperplastic epithelial lesions of the cervix have been observed following the injection of estrogens into mice. Recently a carcinoma of the cervix has been obtained which has grown following transplantation without continuing the administration of estrogen to the host. Several investigators have observed abnormal epithelial growths of the uterine cervices of mice following the injection of estrogens. Loeb, Burns, Suntzeff and Moskop¹reported a precancerous lesion in one mouse. Following the application of estrogen and 1: 2: 5: 6-dibenzanthracene, Perry²and Perry and Ginzton³observed lesions in the cervices of three mice. Localized infiltrating epithelial overgrowths of the cervix were observed in three partially hysterectomized mice and in two mice with intact uteri following estrogen treatment.⁴Recently precancerous or carcinoma-like lesions of the cervix or vagina have been described.⁵ In our laboratory eighteen tumors have been observed in or near