Phosphatidylinositol 3-Kinase Is Necessary for Lens Fiber Cell Differentiation and Survival

Abstract

PI3K signaling regulates lens cell differentiation initiation through its ability to signal reorganization of the actin cytoskeleton from stress fibers to cortical fibers. In differentiating lens fiber cells, PI3K has a protective function, signaling survival through inactivation of its downstream effector GSK3.