Interleukin‐1β induces cytosolic phospholipase a₂ and prostaglandin h synthase in rheumatoid synovial fibroblasts

Abstract

These are the first data to demonstrate the coordinate induction by IL-1 of cPLA2 and PGHS-2 in RSF. The time-course for the induction of these enzymes suggests that their increase contributes to the increased production of PGE2 in IL-1-treated RSF, and may help explain the capacity of RSF to produce large amounts of PGE2.