Biological and Pharmaceutical Bulletin · 1997 · 55 citations · 0 references
ImmunotoxicologyImmunologyPathologyCell DeathImmunotherapyDrug ResistanceInflammationPhytopharmacologyToxicologyPhytochemicalCtl-mediated CytotoxicityGranule ExocytosisGallic AcidPharmacologyHerbal MedicineHerb-drug InteractionChebulagic AcidPhytochemistryMedicine
Gallic acid (GA) and chebulagic acid (CA) were isolated from the extract of a herbal medicine, kashi (myrobalans: the fruit of Terminalia chebula) as active principles that blocked the cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. GA and CA inhibited the killing activity of CD8+ CTL clone at IC50 values of 30 microM and 50 microM, respectively. Granule exocytosis in response to anti-CD3 stimulation was also blocked by GA and CA at the equivalent concentrations.