The Journal of Clinical Endocrinology & Metabolism · 1967 · 29 citations · 0 references
Life SciencesBiochemistryEndocrinologyEndocrine GeneticsHormone BiochemistrySteroid BiochemistryAdrenal DisordersAdrenal EndocrinologyAdrenal HormonesAdrenal Steroid HormonesEndocrine AssessmentEndocrine DiseaseAdrenal Cortex FunctionAdrenal Function AssessmentAdrenal PathophysiologyAdrenal Steroidogenesis DefectsCorticosteroid-binding GlobulinDisorders Of Adrenal SteroidogenesisSerum Total ProteinSteroidogenic Enzyme Defects
A familial decrease in corticosteroid-binding globulin has been described in a 4-generation kindred. The affected family members are healthy and no specific disease states related to this finding have been found. Other estrogen-responsive serum protein concentrations including thyroxine-binding globulin, ceruloplasmin and haptoglobin were normal. There are no signs or symptoms of clinical hypoor hyperfunction of the adrenal glands. Total plasma 17-OHCS concentration was significantly below normal, but the nonprotein-bound 17-OHCS was in the normal range. A urinary loss of 17-OHCS was not evident. The mode of inheritance is not clear.