Synthesis of some new 3‐mercapto‐5‐substituted‐1,2,4‐triazine‐<i>s</i>‐triazoles for evaluation as antimicrobial agents

Abstract

Abstract The synthesis of several S ‐ and N ‐substituted derivatives of 5‐[(5,6‐diphenyl‐1,2,4‐triazin‐3‐yl)oxymethyl]‐ s ‐triazole‐3‐thiol, 2‐[(5,6‐diphenyl‐1,2,4‐triazin‐3‐yl)‐oxymethyl]‐5,6‐dihydrothiazolo‐[3,2‐ b ]‐ s ‐briazole, 2‐[(5,6‐diphenyl‐1, 2,4‐triazin‐3‐yl)oxymethyl]‐5H,6,7‐dihydro‐ s ‐triazolo‐[3,2‐ b ]‐1,3‐thiazine, 2‐[(5,6‐diphenyl‐1,2,4‐triazin‐3‐yl)oxymethyl]‐5,6‐dihydrothiazolo‐[3,2‐ b ]‐ s ‐triazol‐5‐one and 2‐[(5,6‐diphenyl‐1,2,4‐triazin‐3‐yl)oxymethyl]‐6‐phenylthiazolo‐[3,2‐ b ]‐ s ‐triazole is reported. All the novel compounds have been screened for antimicrobial activity and one of them showed noteworthy activity.