Antimicrobial screening of some newly synthesised transition metal complexes of a dithiocarbazate derived from isoniazid

Abstract

Some new metal (II) isonicotinoyldithiocarbazates of the general formula [M(IN-DtczH) 2 ]Cl 2 (M = Mn, Co, Ni, Zn; IN-DtczH = isonicotinoyldithiocarbazic acid) and Mn(IN-Dtcz) 2 , having sulphur-nitrogen linkage were synthesized. All the compounds were screened for their antimicrobial activity against the pathogenic bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus sp . and the pathogenic fungus Candida albicans by agar dilution method. All the compounds showed good antimicrobial activity.