The Control of Oxygen Affinity of Red Cells with Hb‐Shepherds Bush

Abstract

S ummary The red cells of the original patient with Hb‐Shepherds Bush (Hb‐ShB 25%, Hb‐A 75%) have a physiologically significant increased oxygen affinity. This is one third due to the intrinsic raised oxygen affinity of Hb‐ShB and two‐thirds due to its diminished response to 2,3‐DPG, there being no interaction between the two haemoglobins present in the cells.