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An FSH-Producing Pituitary Tumor in a Patient with Hypogonadism
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1974
Year
Human GrowthL-dopa AdministrationGynecologyPathologyFsh-producing Pituitary TumorEmbryologyReproductive EndocrinologyPituitary GlandReproductive MedicinePituitary DiseaseInfertilityGrowth HormoneEndocrine MechanismEnlarged Sella TurcicaEndocrinologyAbsent Growth HormoneAdrenal HealthMedicineEndocrine Research
ABSTRACT A follicle-stimulating hormone-producing pituitary tumor was demonstrated in a 28-yr-old eunuchoid-appearing male who presented with bilateral hemianopsia, oligospermia and an enlarged sella turcica. A basal luteinizing hormone of 16.0 mIU/ml (2nd IRP-HMG) was normal, but FSH was persistently elevated, 33.0–64.0 mIU/ml (normal < 0.8–16.0 2nd IRP-HMG). Provocative testing of hypophyseal function revealed absent growth hormone and deficient thyrotropin and corticotropin release, while prolactin increased normally following thyrotropin-releasing hormone (TRH) and decreased appropriately after l-dopa administration. Plasma testosterone was low. Immunofluorescent staining of the resected chromophobe adenoma using an anti FSH-antiserum revealed uniform fluorescence of the tumor cells. In vitro organ culture of three fragments of this pituitary adenoma demonstrated (mean ± sem) FSH and LH release of 311.7 ± 29.0 mIU/24 hr and 25.6 ± 2.0 mIU/24 hr respectively. No immunoassayable GH or TSH was demonstrab...