Non‐physiological overexpression of the <i>low density lipoprotein receptor</i> (LDLr) gene in the liver induces pathological intracellular lipid and cholesterol storage

Abstract

The non-physiological constitutive overexpression of an LDL receptor gene induces an imbalance between the speed of LDL uptake and metabolism which leads to pathological accumulation of lipids and cholesterol in hepatocytes. To protect cells from negative effects of LDLr overexpression, future vector design should consider the use of physiologically controlled expression elements.