Chlorpromazine-Type Cholangitis

Abstract

SINCE the first case of cholangiolitic hepatitis and jaundice after the administration of chlorpromazine was reported by Zatuchni and Miller,1 numerous papers dealing with various aspects of this problem have appeared in the literature. Recent authors2 3 4 have considered the mechanism of production of this phenomenon to lie in hepatic sensitization to the drug, rather than any of its specific pharmacologic properties. A similar type of cholangitis was reported by Hanger and Gutman5 in 1940 in 12 patients who had been on arsphenamine therapy. Many other compounds have been associated with the appearance of this type of obstructive jaundice, among them . . .