Journal of Liquid Chromatography · 1994 · 12 citations · 6 references
PharmacyPharmaceutical AnalysisPharmacologyBiopharmaceuticsChromatographic AnalysisClinical PharmacologyAnalytical ChromatographyBioanalytical Method ValidationChromatographyClinical AnalysisLiquid ChromatographyBioanalytical ChromatographyBiological Matrix AnalysisHigh-performance Liquid ChromatographyHigh-performance Liquid Chromatography ColumnsHigh-performance Liquid Chromatography Method DevelopmentLower Limit Of QuantificationLower Limit Of QuantitationPlasma Medicine
Abstract A high - performance liquid chromatographic method for the determination of alfuzosin in human plasma has been developed and validated. A column-switching procedure without extraction was used to isolate the drug from biological matrix prior to the quantitative analysis. The lower limit of detection for the analyte was 1 ng/ml. The method was linear from 2 to 150 ng/ml for human plasma. Within- and between-assay precision and accuracy were all found to be <5.2% at the eight concentrations evaluated. This procedure, simple and rapid, is suitable for pharmacology studies on alfuzosin.
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Alfuzosin for treatment of benign prostatic hypertrophy
A Jardin, H. Bensadoun, M. C. DELAUCHE‐CAVALLIER et al. · The Lancet · 1991 · 243 citations
A. Rouchouse, Martine Manoha, Alain Durand et al. · Journal of Chromatography A · 1990 · 28 citations