Trials of Perphenazine in the Prevention of Post-operative Vomiting

Abstract

rare, but perphenazine does produce some adrenergic blockade. There is some potentiating effect on barbiturates and other narcotics, but this effect is much less than with chlorpromazine. With intensive dosage (un- likely in the present application) there may be extra- pyramidal stimulation. The main danger is perhaps that this drug, like chlorpromazine, can obscure the cause of vomiting due to organic disease.