Decreased expression of heparin‐binding epidermal growth factor–like growth factor as a newly identified pathogenic mechanism of antiphospholipid‐mediated defective placentation

Abstract

These preliminary findings suggest that the reduction of aPL-mediated HB-EGF represents an additional mechanism that is responsible for the defective placentation associated with APS and that heparin protects from aPL-induced damage by inhibiting antibody binding.