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Chiral Bifunctional Organocatalysts in Asymmetric Aza-Morita−Baylis−Hillman Reactions of Ethyl (Arylimino)acetates with Methyl Vinyl Ketone and Ethyl Vinyl Ketone
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Citations
7
References
2007
Year
Ethyl Vinyl KetoneChemical EngineeringNovel OrganocatalystsEngineeringMethyl Vinyl KetoneEffective OrganocatalystMild ConditionsOrganic ChemistryOrganometallic CatalysisCatalysisStereoselective SynthesisChemistryAsymmetric CatalysisChiral Bifunctional OrganocatalystsEnantioselective SynthesisBiomolecular EngineeringAsymmetric Aza-mbh Reaction
The bifunctional chiral phosphine Lewis base (R)-2'-diphenylphosphino-[1,1'-binaphthalene]-2-ol is an effective organocatalyst in the asymmetric aza-MBH reaction of ethyl (arylimino)acetates 1 with MVK and EVK to give the corresponding adducts in moderate to good yields and good to high enantiomeric excesses under mild conditions.
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