Publication | Closed Access
ULTRAVIOLET AND γ‐RAY‐INDUCED REACTIONS OF NUCLEIC ACID CONSTITUENTS. REACTIONS OF PURINES WITH AMINES
38
Citations
16
References
1974
Year
Ultraviolet RadiationBioorganic ChemistryNucleic Acid ChemistryPhotochemistryBiochemistryNatural SciencesPurines With AminesMechanistic PhotochemistryNucleic Acid BiochemistryPhotobiologyMolecular BiologyOrganic ChemistryFree Radical MechanismPhotosensitizersRadiation ChemistryDna‐protein Cross‐linksBiomolecular EngineeringHealth Sciences
Abstract— Photochemical and γ‐ray‐induced reactions of purines with amines are described. These lead to the appropriate 8‐substituted purines. The photoproducts were obtained in yields of up to 100% by the use of a variety of photosensitizers, including peroxides. A free radical mechanism is proposed for these reactions. Such reactions may be relevant to the problem of the nature of DNA‐protein cross‐links induced by ultraviolet radiation.
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