Renal Failure · 1997 · 13 citations · 2 references
MedicineInternal MedicinePharmacotherapyRenal PathophysiologyRenal PharmacotherapyAcute Kidney InjuryEosinophilic DisordersInterstitial NephritisPeptic Ulcer DiseasePeptic Ulcer PharmacotherapyRenal DiseaseDrug-induced Acute Kidney InjuryEosinophilic Interstitial NephritisPeptic Ulcer Disease PathophysiologyProton Pump Inhibitor - Induced Interstitial NephritisRenal Failure Management
Omeprazole is a proton pump inhibitor widely used for the treatment of peptic ulcer disease. We report a patient presenting nonoliguric acute renal failure following omeprazole treatment. Both eosinophilia and eosinophiluria were observed, and the patient was diagnosed as having drug-induced acute interstitial nephritis. Renal failure spontaneously resolved when omeprazole was discontinued.
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