Exogenous Collagen Crosslinking of the Intervertebral Disc Restores Joint Stability After Lumbar Posterior Decompression Surgery

Abstract

Injections of crosslinking reagents into lumbar intervertebral discs after simulated decompression surgery restored joint stability according to all parameters. Similar results were found for genipin and methylglyoxal reagents. Implementing exogenous collagen crosslinking as an adjunct to current surgical decompression procedures may be beneficial in preventing or delaying subsequent spinal instability and degeneration.