Diversity of human papillomavirus types in periungual squamous cell carcinoma

Abstract

In contrast to other locations of the hands, periungual SCCs are frequently associated with alpha-HPV infections. Several high-risk HPV types other than HPV16 can induce periungual SCCs. Given the high recurrence rate and high proliferative activity of HPV-associated periungual SCCs, aggressive treatment and close follow-up of these tumours is mandatory.