Is Topical δ-Aminolevulinic Acid Adequate for Photodynamic Therapy in Barrett’s Esophagus? A Pilot Study

Abstract

Low-dose topical administration of delta-ALA provides ablation of low-grade dysplasia in the range obtained with oral delta-ALA. In addition, it is safe and well tolerated. Since, however, topical administration of delta-ALA is not able to consistently eradicate Barrett's esophagus, alternative methods will have to be developed.